2009 Mar 2;134(3-4):267-71. doi: 10.1016/j.vetmic.2008.08.021. Epub 2008 Aug 28.Mathes KA, Radelof K, Engelke E, Rohn K, Pfarrer C, Fehr M.PLoS One. ACVP members can log in in using their ACVP credentials below.J. This article describes a newly recognized highly malignant neoplastic entity in young bearded dragons (Pogona vitticeps), gastric neuroendocrine carcinomas, which readily metastasize. Unable to load your collection due to an error This panel included IHC to detect protein gene product 9.5 (PGP9.5), synaptophysin, gastrin, glucagon, chromogranins A and B, insulin, neuron-specific enolase (NSE), endorphin, somatostatin, vasoactive intestinal peptide (VIP), pancreatic polypeptide (PPP), and neurofibromin.
2019 Aug 22;14(8):e0221050. Ten bearded dragons with histories of anorexia (8), vomiting (3), hyperglycemia (2), and anemia (3) were included in this study. In all 5 animals examined, neoplasms exhibited decreased neurofibromin expression compared with control tissues, suggesting that decreased functional neurofibromin may play a role in the pathogenesis of somatostatinomas in bearded dragons. Metastases were identified in the liver of all 10 animals as well as in other organs in some animals: kidney (6), pancreas (3), intestine (2), heart (2), oviduct (2), and ovary (1). Microscopically, 6 of these neuroendocrine carcinomas were well-differentiated and 4 were poorly differentiated.
Sign in here to access free tools such as favourites and alerts, or to access personal subscriptionsIf you have access to journal content via a university, library or employer, sign in hereResearch off-campus without worrying about access issues. In contrast to humans, somatostatinomas in bearded dragons appear to be primarily of gastric origin, but similar to their human pancreatic counterpart, exhibit widespread metastases and may be associated with a clinical syndrome of hypersomatostatinemia.
We also thank the Electron Microscopy Core Laboratory, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida.
Epub 2018 Jun 2.
A. Chilton, E. R. Jacobson, and M. KiupelDiagnostic Center for Population and Animal Health and Department of Pathobiology and Diagnostic Investigation, Michigan State University, Lansing, MIVeterinary Medical Teaching Hospital, University of Wisconsin, Madison, WIDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FLDiagnostic Center for Population and Animal Health and Department of Pathobiology and Diagnostic Investigation, Michigan State University, Lansing, MIDiagnostic Center for Population and Animal Health and Department of Pathobiology and Diagnostic Investigation, Michigan State University, Lansing, MIVeterinary Medical Teaching Hospital, University of Wisconsin, Madison, WIDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL Always track your beardie’s weight and if they stop eating and are losing weight, see a vet. Pythiosis (Oomycosis, Lagenidiosis, Swamp Cancer, Bursatti, Leeches) in Dogs, Cats and Horses. Eight animals (Nos. Samples were then dehydrated in a graded ethanol series followed by 100% acetone, infiltrated in a graded ethanol/Spurr's resin (Spurr Embedding Kit, Ted Pella Inc., Redding, CA) series, and polymerized in 100% Spurrs at 60Gross necropsy findings were available for 9 of the 10 bearded dragons.
Atypon Name must be less than 100 characters In cases of multihormonal expression, one hormone typically predominates, with others present in minor, varying amounts. Rabies in Animals. The cause for the bearded dragon's apparent predisposition to this otherwise unusual neoplasm is unknown. 1, 2, 3, 4, 5, 7, 8, and 9) were from Northwest ZooPath, 2 animals (Nos. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Decreased functional neurofibromin protein may play a role in the pathogenesis of these tumors, and further genetic studies are necessary to investigate this pathway. Simply select your manager software from the list below and click on download. Some of these IHC markers have previously been shown to exhibit cross-reactivity in other reptile species.Electron microscopy was performed on tissue from bearded dragon No. Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website.Duodenal somatostatinomas associated with von Recklinghausen diseaseAn histological and immunocyto-chemical study of the neuroendocrine cells in the intestine of Hematology of reptiles and clinical chemistry of reptilesImmunohistochemical localization of chromogranin A and B in endocrine cells of the alimentary tract of the adult lizard Reptile neoplasia: a retrospective study of case submissions to a specialty diagnostic serviceChronic monocytic leukemia in an inland bearded dragon, The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2Overview of reptile biology, anatomy, and histologyLoss of the neurofibromin-NFI gene product and composite pheochromocytomaTumors of the islets of Langerhans and tumors of dispersed endocrine cellsMulticentric benign peripheral nerve sheath tumors in two related bearded dragons, Histological and immunocytochemical study of the endocrine pancreas of the lizard Von Recklinhausen's disease associated with duodenal somatostatinoma: contrast of duodenal versus pancreatic somatostatinomaPancreatic endocrine tumors are a rare manifestation of the neurofibromatosis type 1 phenotypeTumorigenesis in neurofibromatosis: new insights and potential therapiesImmunohistology of neuroendocrine and neuroectodermal tumorsNeurofibromin, a tumor suppressor in the nervous system